Osteoarthritis, the most common form of arthritis, is a major cause of functional disability as we age. When comparing the chronic diseases suffered by the elderly, osteoarthritis and osteoporosis are known to be the most common conditions.
The prevalence of co-morbid conditions makes treating the elderly osteoarthritis patients different from other populations. Many of these patients are on numerous medications which can have interactions or serious side effects. Therefore, the treatment or management of a variety of conditions in the elderly population can be a challenge.
Although there is a substantial amount of scientific and clinical research on osteoarthritis, there is no uniform agreement regarding the cause and pathogenesis of the condition. It is generally agreed that cause is multifactorial.
The most common nutrients offered on the market today in support of connective tissues are glucosamine, chondroitin, collagen hydrolysates, MSM, and hyaluronic acid.
According to a study published two weeks ago in the International Journal of Molecular Sciences, researchers demonstrated a protective role of ascorbic acid on osteoarthritic osteoblasts.
In this study, the research team isolated human osteoarthritic subchrondral bone. They showed that vitamin C had a significant effect on cell proliferation and slightly larger percentages of alkaline phosphatase and osteocalcin.
Vitamin C is a powerful antioxidant that is protective against excessive free radical formation that can cause cell death. Free radicals and oxidative stress play a significant role in the dysfunction and decreased number of osteoblasts during aging. This study demonstrates that vitamin C can be used to counteract oxidative stress and increase the life span of osteoblasts.
In addition, ascorbic acid is required for the hydroxylation of amino acids for the synthesis of collagen, and an insufficiency is associated with defects in connective tissue repair. Therefore, supplementing with nutrients such as collagen, glucosamine sulfate, and vitamin Care protective and can help mitigate connective tissue degeneration associated with osteoarthritis.