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Diabetic Complications Treated with Hyperbaric Oxygen Therapy

Diabetic Complications Treated with Hyperbaric Oxygen Therapy

By Dr. Patrick Lovegrove, Medically Reviewed by Lindsay Langley, BSN, RN, CHT
Posted Friday, April 18th, 2025
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Did you know that hyperbaric oxygen therapy (HBOT) can do more than speed up healing? It can help treat specific complications of diabetes, such as chronic wounds that refuse to heal. Diabetes can be unforgiving, leading to severe conditions like foot ulcers and infections that threaten the need for amputation. But with the help of advanced treatments like HBOT, there’s hope for recovery.

In this article, we’ll explore which complications of diabetes can be treated with hyperbaric oxygen, how this therapy works, and who can benefit most. Whether you’re looking for alternative treatment options or want to understand the science behind HBOT, this guide will give you the answers you need.

Overview of Hyperbaric Oxygen Therapy (HBOT) in Diabetes Care

Hyperbaric Oxygen Therapy (HBOT) is a specialized medical treatment where patients breathe 100% oxygen in a pressurized chamber. This increased pressure allows the oxygen to dissolve more efficiently into the bloodstream, promoting faster healing and reducing inflammation. For people with diabetes, this therapy has proven particularly useful in managing complications that arise due to poor circulation and impaired wound healing, two common issues in diabetic patients.

Why Is HBOT Important for Diabetics?

People with diabetes are at a higher risk of developing chronic wounds, particularly in their feet (diabetic foot ulcers), due to reduced blood flow and nerve damage. These wounds often heal slowly, and in severe cases, they can lead to infections, gangrene, and even amputation. HBOT offers a promising treatment by:

  • Enhancing oxygen delivery to damaged tissues, improving the body’s natural healing process.
  • Stimulating new blood vessel formation (angiogenesis), which is crucial for wound repair.
  • Reducing swelling and controlling infection by increasing the effectiveness of white blood cells.
  • Minimizing the need for more invasive treatments, such as surgery or amputations.

What to Expect During Hyperbaric Oxygen Therapy

  • Duration: Sessions typically last around 90 minutes to two hours, depending on the severity of the condition.
  • Frequency: Patients may need between 20 and 40 sessions over several weeks for optimal results.
  • Comfort: Inside the hyperbaric chamber, you can sit or lie while receiving the treatment, and some chambers are large enough to allow light movement.

By improving oxygen delivery to areas with poor blood flow, HBOT has become a valuable tool for treating diabetic complications. It is especially useful for chronic wounds that do not heal with standard treatments.

How Does Hyperbaric Oxygen Therapy Work?

Hyperbaric Oxygen Therapy (HBOT) works by delivering high levels of oxygen in a pressurized chamber. While it may sound complex, the science is straightforward and highly effective, particularly for diabetic patients with difficult-to-treat wounds.

The Science Behind HBOT

Under normal conditions, red blood cells carry oxygen through your body. In HBOT, air pressure increases to about two or three times the normal level. This forces more oxygen into your bloodstream. The oxygen dissolves directly into your plasma, tissues, and fluids. As a result, it can reach areas that red blood cells can’t access due to damage or blockages.

Here’s how HBOT benefits your body:

BenefitDescription
Increased Oxygen DeliveryThe therapy boosts oxygen levels in the blood, allowing it to reach damaged or oxygen-starved tissues that struggle to heal due to poor circulation, which is common in diabetics.

Enhanced Healing and Tissue Repair
Higher oxygen levels promote collagen production and the formation of new blood vessels (angiogenesis), which are essential for tissue repair and wound healing.
Reduced Inflammation and SwellingThe pressurized oxygen helps decrease inflammation, providing relief from swelling, which is often a barrier to healing in diabetic wounds.

Improved Immune Response
HBOT enhances the ability of white blood cells to kill bacteria and reduces the harmful effects of infection, which is a frequent complication in diabetic ulcers.

Prevention of Tissue Death
For severe wounds like diabetic foot ulcers, HBOT helps to prevent necrosis (tissue death), reducing the likelihood of needing amputations.

What Happens in a Session?

During a typical HBOT session:

  • The Patient is Seated or Lying Down: Patients are placed in a hyperbaric chamber where they breathe pure oxygen while the pressure is gradually increased.
  • Pressure Increases Gradually: As the pressure builds, oxygen molecules are pushed into your bloodstream and surrounding tissues.
  • Treatment Lasts 1-2 Hours: Most sessions last about 90 minutes to two hours, with patients typically needing multiple sessions for maximum benefit.

By saturating the body with oxygen in this way, HBOT helps accelerate the healing of wounds and other complications related to diabetes, offering a non-invasive and supportive therapy for those struggling with chronic conditions.

Identifying Common Diabetic Wound Issues Requiring HBOT

For individuals with diabetes, wounds—particularly those on the feet—can evolve into serious health issues. When these wounds fail to heal properly, they can lead to severe complications, including infections, gangrene, and the risk of amputation. Hyperbaric Oxygen Therapy (HBOT) has proven to be a game-changing treatment for certain types of diabetic wounds, offering hope for healing when standard care falls short.

Common Diabetic Wound Issues

  1. Diabetic Foot Ulcers
    • Cause: Diabetic foot ulcers develop due to a combination of nerve damage (neuropathy) and poor circulation (peripheral artery disease).
    • Characteristics: These open sores often occur on the soles of the feet or around the toes. Due to reduced sensitivity in the feet, many people with diabetes may not realize they have a wound until it becomes infected.
    • Why HBOT Helps: HBOT can speed up the healing process by delivering oxygen to the affected tissues, reducing the risk of infection, and promoting the growth of new blood vessels.
  2. Venous Stasis Ulcers
    • Cause: These ulcers form when veins in the legs fail to circulate blood back to the heart effectively, leading to pooling and increased pressure in the lower extremities.
    • Characteristics: Venous stasis ulcers are often painful and develop slowly, usually near the ankles. They can become chronic and difficult to heal.
    • Why HBOT Helps: By improving oxygenation in the tissues, HBOT can reduce swelling and inflammation while enhancing tissue regeneration.
  3. Pressure Ulcers (Bedsores)
    • Cause: Pressure ulcers occur when prolonged pressure cuts off circulation to the skin and underlying tissues. They often affect bedridden patients or those with limited mobility.
    • Characteristics: These ulcers are typically found on the heels, hips, or back and can range from mild skin reddening to deep wounds that expose muscle and bone.
    • Why HBOT Helps: HBOT improves oxygen flow to these damaged tissues, reducing the risk of further tissue breakdown and infection.
  4. Ischemic Wounds
    • Cause: These wounds develop due to severely restricted blood flow to the affected area, often seen in patients with advanced diabetes and peripheral artery disease.
    • Characteristics: Ischemic wounds tend to be painful, slow to heal, and can quickly escalate into infections or gangrene.
    • Why HBOT Helps: By delivering oxygen to starved tissues, HBOT can stimulate blood flow and accelerate healing, even in areas with poor circulation.

Indicators That HBOT May Be Needed

  • Chronic Non-Healing Wounds: If a wound shows no signs of improvement after several weeks of conventional treatment, HBOT may be considered to stimulate healing.
  • Infection and Tissue Necrosis: When a wound becomes infected or begins showing signs of tissue death, such as discoloration or foul odor, HBOT can help control infection and reduce further damage.
  • High Risk of Amputation: For patients at risk of amputation due to non-healing ulcers, HBOT can potentially save limbs by promoting tissue regeneration and reducing inflammation.

When to Seek HBOT

If you or a loved one is experiencing a wound that isn’t healing or is showing signs of infection, consulting with a medical professional about HBOT could be a vital step toward recovery. This therapy may be particularly beneficial for patients who have exhausted traditional treatment options without success.

Clinical Evidence Supporting HBOT for Wound Healing in Diabetic Patients

Hyperbaric Oxygen Therapy (HBOT) has been increasingly recognized as a valuable treatment option for non-healing diabetic wounds, such as foot ulcers. Several clinical studies and trials support its effectiveness in accelerating wound healing, reducing complications, and improving patient outcomes. Here, we’ll explore the key clinical evidence that reinforces HBOT as a viable option for diabetic wound care.

Key Studies on HBOT for Diabetic Wound Healing

  1. Diabetic Foot Ulcers and HBOT: A Meta-Analysis
    • Study Overview: A meta-analysis on diabetic foot ulcers reviewed several randomized controlled trials (RCTs) to assess how effective HBOT is.
    • Findings: Patients who received HBOT had much higher rates of complete wound healing than those who received only standard care. The therapy also lowered the risk of amputations in patients with chronic foot ulcers.
    • Conclusion: The results strongly support HBOT as a valuable addition to diabetic foot ulcer treatment. It is especially effective in helping prevent amputations.
  2. The Effect of HBOT on Wound Healing and Amputation Rates
    • Study Overview: An RCT focused on patients with advanced diabetic foot ulcers who had not responded to conventional treatment.
    • Findings: Patients who received HBOT had a 61% higher wound closure rate. They also showed a 40% lower risk of amputation compared to the control group.
    • Conclusion: The study confirmed that HBOT is effective in promoting wound healing and helping diabetic patients avoid limb loss.
  3. HBOT for Chronic Wounds: Long-Term Outcomes
    • Study Overview: A long-term observational study followed patients who underwent hyperbaric oxygen therapy (HBOT) for chronic diabetic wounds over a 3-year period.
    • Findings: HBOT not only sped up healing but also reduced the chances of wound recurrence and infection in the years after treatment.
    • Conclusion: HBOT provides durable benefits beyond immediate wound healing, contributing to long-term wound management and prevention.

How HBOT Improves Clinical Outcomes

BenefitClinical Evidence
Faster Wound HealingNumerous studies, including meta-analyses and RCTs, demonstrate that HBOT significantly accelerates the healing of chronic diabetic wounds compared to standard care alone.
Reduced Amputation RatesClinical trials reveal that HBOT can dramatically lower the risk of amputations, particularly in patients with advanced diabetic foot ulcers, by improving tissue oxygenation and promoting repair.
Enhanced Quality of LifeStudies have shown that patients undergoing HBOT report better outcomes in terms of pain relief, mobility, and overall quality of life as their wounds heal more rapidly.

FDA Approval and Medical Guidelines

  • FDA Approval: HBOT is FDA-approved for the treatment of chronic diabetic wounds, specifically those that are classified as severe or non-healing. This approval underscores its recognized role in managing diabetic complications.
  • Clinical Guidelines: The Undersea and Hyperbaric Medical Society (UHMS) and the American Diabetes Association (ADA) both recommend HBOT for certain diabetic wound cases. It is especially advised for patients who have not responded to standard treatments.

The Bottom Line

Clinical evidence strongly supports the effectiveness of HBOT. Many studies confirm that it helps wounds heal faster and lowers the risk of amputation in diabetic patients. As more healthcare providers incorporate HBOT into diabetic care plans, patients can expect improved outcomes and a better quality of life.

Hyperbaric Oxygen Therapy (HBOT) offers hope for diabetic patients struggling with chronic wounds. Backed by clinical evidence, HBOT accelerates healing, reduces the risk of amputation, and improves quality of life. If conventional treatments fall short, hyperbaric oxygen therapy (HBOT) may be a solution worth exploring.

Conclusion

In conclusion, hyperbaric oxygen therapy (HBOT) is a powerful and promising treatment for diabetic complications. It works by delivering concentrated oxygen to damaged tissues. This process accelerates healing, reduces inflammation, and enhances circulation. HBOT is especially helpful for chronic wounds, neuropathy, and other diabetes-related issues that don’t respond well to standard care.

For those dealing with long-term diabetic complications, HBOT provides relief and the chance to improve quality of life. It’s a proactive, non-invasive therapy that supports the body’s natural healing. Hyperbaric oxygen therapy (HBOT) can be an important part of a comprehensive diabetes management plan.

👉 Want to know if HBOT is right for your condition? Contact Merge Medical Center today to schedule a consultation and explore a personalized treatment plan designed to help you heal from the inside out.

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Author:

Dr. Patrick Lovegrove