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Hormone Pellets Therapy Service in Charleston, South Carolina

What is Hormone Pellet Therapy?

Manufacturing hormone pellets to be bio-identical to your own body's hormones. They mostly come from extracts from natural sources, e.g., soy and yam. Using bioidentical hormones is reported to be effective in augmenting levels or replacing what a patient does not make. The hormone is implanted in the subcutaneous skin. It releases small, physiologic doses of hormones regulated by a patient's cardiac output to provide optimal therapy.

One of the reported advantages of hormone pellets over typical oral and transdermal creams or patch forms of therapy. Which produces “roller coaster” hormone levels resulting in mood and energy fluctuations for the patient.

Hormone Pellet Therapy is the only method of hormone replacement therapy that provides sustained hormone levels throughout the day for up to 3 to 6 months without any “roller coaster” effect. The pellets have a physiologic pulsatile dosing effect. It parallels the patients' needs based on cardiac output and demands.

For instance, during exercise, there is a more significant release of the hormone from the pellet. Very similar to what a person's body would have done naturally from ovaries, adrenals, and testicles.

What are Hormone Pellets?

The pellets' compounds consist of estrogen or testosterone from a plant source, e.g., soy or yam. We do this simple, pain-free procedure in the office under local anesthesia. These pellets are about the size of a grain of rice or "tic-tac." They are placed in the fatty tissue underneath the skin around the buttock, hip, or abdominal area through a small incision that requires no sutures or stitches. It just closed with butterfly-style bandages.

What is the history of pellets being used for a hormonal replacement?

Humans have been using pellets Since the late 1930s. More data supports the use of pellets than any other method of delivery of hormones. Pellets are not patented and not marketed in the United States. Different areas, such as Europe and Australia, frequently use it. Pharmaceutical companies manufacture hormone pellets.


Most of the research on pellets is out of:

  • England
  • Australia
  • Germany
  • Netherlands


Some of the most exciting data on hormone implants in breast cancer patients are out of the United States. Showing a reduction in breast cancer incidence in patients taking testosterone pellets.

What are some advantages of Pellets for hormone replacement?

Comp pellets are far superior in studies and routine patient reporting compared to conventional hormone replacement therapy.


Below are the advantages of pellets for hormone replacement.

  •  Relief of menopausal symptoms.
  • Maintenance of bone density.
  • The re-establishment of better sleep patterns.
  • Enhancement in sex drive, erectile response, and sexual performance.

 Also, when on hormone replacement therapy, the following has been reported:

  • An Increase in energy
  • Sense of well-being
  • Increased muscle mass and strength, and stamina.
  • Decreased frequency and severity of migraine headaches.
  • Decrease in mood swings, anxiety, and irritability.
  • Decreased obesity.
  • Reduction in risk or severity of diabetes.
  • Reduced risk of heart disease.
  • Reduced risk of Alzheimer’s and dementia.

Frequently Asked Questions About Hormone Pellets And Hormone Replacement


      • What are the potential complications of inserting hormone pellets? Rare complications from the insertion of pellets include trivial bleedingbruisingdiscoloration of the skininfection, and extrusion of the pellet, aka it “pops back out.” Avoid extended exposure to moisture (swimming, hot tubs, bathtubs) for 4 to 5 days, and avoid vigorous physical activity for 48 hours in women and up to 5 to 7 days in men. Sometimes a patient who has diabetes or just had a recent joint replacement may need antibiotics as a precaution after the pellet insertion.


      • What are the most common side effects when the first insert of pellets? When a patient starts bioidentical hormone therapy, there may be mild, temporary breast tenderness, which gets better. Hormone receptors may be susceptible and take time to adjust. There may be a quick water weight gain that will resolve on its own. The body will tone up as bone density and muscle mass increase and fatty tissue decrease. Patients may experience a mild form of “puberty” as their hormonal levels come up into normal ranges and the body “wakes up” from its hibernation.


      • What can I expect after pellet insertion? After inserting the pellets, patients may notice more energy, enhanced sleep, sex drive, improved mood, and overall physical health. They are expecting muscle mass to increase while the percentage of body fat diminishes. Bone density should improve and even normalize. Patients may feel more vigorous and notice better coordination, physical stamina, and performance. Many patients note an improvement in skin tone and hair texture. Often Brain speed increases and thus enhances concentration and memory.


      • How soon will I feel the effects of the pellets? Some patients notice the results within 24-48 hours, while others may take 1-2 weeks to see a change.


      • How long before replacing the hormone pelletsThe pellets usually last between 3-5 months in women and 5-6 months in men. High levels of stress, physical activity, advanced age, some prescriptions, and poor sleep may change the rate at which the pellet absorbs. It may require that pellets are inserted sooner or later in those cases.


      • Do the pellets need to be removed? No, it does not need to remove the pellets. They completely dissolve on their own.


      • Do men need hormone replacement? Testosterone levels begin to decline in men in their late 20s or early 30s. Many men maintain “normal” levels of testosterone into their mid-40s to mid-’50s and then slowly start to decline over the years. Men should get a lab test when they notice symptoms or signs of low testosterone. Even men at age 30 can have low T and show signs of bone loss. A man is never too old to benefit from hormone therapy.


      • Do women also need to take progesterone when they use the pellets? Prescribing estradiol and progesterone at any time. There are progesterone (not synthetic progestin) receptors in the bone, brain, heart, breast, and uterus. Use progesterone as a topical cream, vaginal cream, oral capsule, or sublingual drops or tablets. If a patient is pre-menopausal, she may use the progesterone during the last two weeks of the menstrual cycle or as directed by the hormone doctor.


      • Do women need to be in menopause to benefit from pellets? Using hormone therapy with pellets is not just for women experiencing menopause. Women at any age may experience hormone imbalance. Levels decline or fluctuate, contributing to debilitating symptoms. Pellets can improve severe PMSdepressionmenstrual or migraine headaches, and sleeping issues. Use pellets to improve hormone deficits induced by taking birth control pills.


      • How are the hormones monitored during therapy? Hormone lab levels are evaluated before hormone therapy begins. It will include an FSH estradiol, Sex Hormone binding globulin, and testosterone. Lab levels will be reanalyzed during hormone therapy around six weeks post-insertion and as needed. After one year of treatment, hormone levels are less often.





  • Julian Whitaker and MD. Dr. Whitaker’s.
    Guide to Natural Hormone Replacement.
    Phillips Publishing, Maryland 1997.
  • R. Livesey, MD and J Raffaele, MD.
    A Woman’s Guide to Bioidential Hormone Replacement and Anti-Aging Therapies/ PhysioAge Medical Group.
    Facts About Menopausal Hormone Therapy. U.S. Department of Health and Human Services.
    National Institutes of Health.
  • Dr. Dan Hale
    Feel Younger, Stronger, Sexier: The Truth about Bio-Identical Hormones.
    Published: June 17, 2019.
    Publisher: First Edition Design Publishing.
  • Katherine Sherif, MD.
    Hormone Therapy: A Clinical Handbook.
    Published: Springer on May 14, 2013.


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