Exercise and Improved Cognition
By Dr. Patrick Lovegrove Medically Reviewed by Lindsay Langley, BSN, RN, CHT
Posted Friday, November 9th, 2018
A new study by a Massachusetts General Hospital research team found that exercise is one of the best ways to improve cognitive function and turn on neurogenesis, the process of producing new neurons. Neurogenesis takes place in the hippocampus and striatum and is essential to learning and memory. Because beneficial effects on cognition are often blocked in patients with Alzheimer’s disease (AD) due to the “hostile inflammatory environment” in the brain, the MGH team set out to see what impact adult hippocampal neurogenesis (AHN) has on AD pathology and if this could reduce symptoms associated with AD.
They demonstrated that exercise improves cognitive function by inducing neurogenesis in the mouse model, and they were also able to mimic these beneficial effects through gene therapy and pharmacological agents. What they found was that the animals with AHN induced by exercise showed improved cognitive function and reduced levels of beta-amyloid. The new neurons in the other cohort, however, induced by gene and pharmacological therapy, could not survive in the brain already ravaged by AD.
The study concluded that “the key difference was that exercise also turned on the production of brain-derived neurotrophic factor (BDNF), which is known to be important for the growth and survival of neurons.” BDNF helped create a more hospitable brain environment for the new neurons to survive. [Thus,] “by combining drugs and gene therapy that both induced neurogenesis and increased BDNF production, they were able to successfully mimic the effects of exercise on cognitive function.”
Creating new nerve cells is not enough. Survival and growth of new cells are dependent on a hospitable “cleaned up” environment, which exercise was found to foster.
About the author
Dr. Patrick Lovegrove
Dr. Patrick Lovegrove is board certified by the American Board of Family Physicians. He was born in Staunton, Virginia, and graduated from the University of Virginia where he majored in Biology. He received a Medical School Scholarship from the United States Air Force. A graduate of Nova Southeastern College of Osteopathic Medicine, his over 20 years of clinical experience includes Family Practice, Anti-aging, Holistic Internal Medicine, Pain Management, Aerospace, Sports, and Emergency Medicine. He believes that holistic medicine should be integrated with conventional medicine in a scientifically based model to achieve the best results for patients.