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Premenstrual Dysphoric Disorder (PMDD) and Ehlers-Danlos Syndrome (EDS): Understanding the Connection

Premenstrual Dysphoric Disorder (PMDD) and Ehlers-Danlos Syndrome (EDS): Understanding the Connection

By Dr. Patrick Lovegrove, Medically Reviewed by Lindsay Langley, BSN, RN, CHT
Posted Sunday, March 30th, 2025
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Understanding Premenstrual Dysphoric Disorder (PMDD)

What is PMDD?

Have you ever felt that your premenstrual symptoms go far beyond the usual discomfort of PMS? Premenstrual Dysphoric Disorder (PMDD) is a severe mood disorder that occurs in the luteal phase of the menstrual cycle, significantly impacting daily life. Unlike PMS, PMDD leads to intense emotional and physical symptoms that can be debilitating. While the exact cause remains unclear, hormonal fluctuations—particularly involving estrogen and progesterone—are believed to play a key role.

Studies suggest that approximately 3-8% of women of reproductive age experience PMDD. Recognizing and addressing these symptoms can make a world of difference in managing the condition.

Symptoms of PMDD

PMDD symptoms often mimic those of other mood and anxiety disorders, making diagnosis challenging. Common symptoms include:

Emotional Symptoms:

  • Intense mood swings
  • Irritability or anger
  • Anxiety or overwhelming tension
  • Depression or feelings of hopelessness

Physical Symptoms:

  • Fatigue or lack of energy
  • Sleep disturbances
  • Changes in appetite (cravings or overeating)
  • Headaches or breast tenderness

How is PMDD Diagnosed?

If you suspect you have PMDD, tracking symptoms over at least two menstrual cycles is crucial. Healthcare professionals often use the DSM-5 criteria for diagnosis, ensuring that symptoms are recurrent and significantly impact daily activities.

The Impact of PMDD on Daily Life

PMDD can disrupt work, relationships, and overall well-being. Imagine trying to focus on an important project while battling anxiety, exhaustion, and mood swings. It’s not just about feeling “off” for a few days—it’s a recurring struggle that affects every aspect of life.

Effects on:

  • Work Performance: Difficulty concentrating, missed deadlines, and reduced productivity.
  • Relationships: Increased strain with family, friends, and partners due to mood fluctuations.
  • Physical Health: Chronic fatigue and discomfort can make maintaining a healthy lifestyle difficult.

Understanding PMDD is the first step in taking control and finding effective management strategies.


Ehlers-Danlos Syndrome (EDS): A Complex Connective Tissue Disorder

What is EDS?

Ehlers-Danlos Syndrome (EDS) is a group of rare genetic disorders affecting connective tissues, which provide support to the skin, joints, and blood vessels. People with EDS often experience joint hypermobility, skin that bruises easily, and chronic pain.

Common Types of EDS

Each type of EDS presents unique challenges:

  • Hypermobile EDS (hEDS): Characterized by joint hypermobility, frequent dislocations, and chronic pain.
  • Classical EDS (cEDS): Marked by stretchy skin, easy bruising, and a higher risk of organ rupture.
  • Vascular EDS (vEDS): The most severe form, with fragile blood vessels that may lead to life-threatening complications.

Diagnosing EDS

EDS diagnosis typically involves:

  • Clinical Evaluation: Assessing joint flexibility, skin elasticity, and family history.
  • Genetic Testing: Identifying collagen-related mutations.
  • Beighton Score: A tool used to measure joint hypermobility.

EDS symptoms vary widely, making early recognition essential for effective management.


The Link Between PMDD and EDS

Emerging Research and Shared Symptoms

Recent studies suggest that women with EDS may be more likely to experience PMDD. Why? The interplay between hormonal fluctuations and connective tissue abnormalities may intensify symptoms. Research published in the American Journal of Medical Genetics indicates that increased joint laxity and chronic pain associated with EDS may contribute to PMDD’s emotional and physical distress.

Common Overlapping Symptoms:

  • Chronic Pain: Persistent discomfort in both conditions.
  • Mood Disorders: Anxiety and depression linked to physical symptoms and hormonal changes.
  • Fatigue: Profound exhaustion is a hallmark of both PMDD and EDS.

This connection highlights the need for a multidisciplinary approach to diagnosis and treatment.


Managing PMDD and EDS Together

Multidisciplinary Approach

Managing both PMDD and EDS requires collaboration between specialists, including:

  • Gynecologists: To address hormonal treatments.
  • Rheumatologists: For joint and connective tissue concerns.
  • Mental Health Professionals: Providing therapy and coping strategies.
  • Physical Therapists: Helping to maintain joint stability with customized exercise plans.

Lifestyle Changes for Symptom Management

Adopting specific lifestyle habits can help ease symptoms:

  • Mindfulness & Stress Reduction: Yoga, meditation, and deep breathing exercises.
  • Balanced Nutrition: Eating anti-inflammatory foods rich in omega-3s, vitamins, and minerals.
  • Gentle Physical Activity: Low-impact exercises like swimming or walking to support joint health.
  • Good Sleep Hygiene: Prioritizing rest and creating a bedtime routine.

Medical Interventions

For those needing additional support, medical treatments may include:

  • Hormonal Therapies: Birth control or hormone therapy to regulate PMDD symptoms.
  • Pain Management: Over-the-counter or prescription medications for EDS-related pain.
  • Cognitive Behavioral Therapy (CBT): Effective for managing emotional symptoms.

Support & Resources for Individuals with PMDD and EDS

Advocacy Organizations

Connecting with advocacy groups can provide valuable resources and support:

  • PMDD: International Association for Premenstrual Disorders (IAPMD)
  • EDS: The Ehlers-Danlos Society

Online Communities

Engaging in online support groups can offer guidance and encouragement. Platforms like Facebook, Reddit, and dedicated forums host communities where individuals share coping strategies and experiences.

Seeking Professional Help

If you suspect you have PMDD, EDS, or both, consider:

  • Keeping a symptom journal for tracking patterns.
  • Seeking specialists who understand both conditions.
  • Advocating for a comprehensive treatment plan.

Final Thoughts

Living with PMDD and EDS presents unique challenges, but with the right approach, symptoms can be managed effectively. By seeking medical support, adopting lifestyle changes, and engaging with supportive communities, individuals can take control of their health and improve their quality of life.

At Merge Medical Center, we are dedicated to providing holistic, patient-centered care to help you navigate these complex conditions. If you or a loved one are struggling with PMDD or EDS, reach out today to explore personalized treatment options and support.

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Author:

Dr. Patrick Lovegrove